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Deterministic Effects – Ionizing Radiation

Deterministic effects (or non-stochastic health effects) are health effects, that are related directly to the absorbed radiation dose and the severity of the effect increases as the dose increases. Deterministic effects have a threshold below which no detectable clinical effects do occur. The threshold may be very low (of the order of magnitude of 0.1 Gy or higher) and may vary from person to person. For doses between 0.25 Gy and 0.5 Gy slight blood changes may be detected by medical evaluations and for doses between 0.5 Gy and 1.5 Gy blood changes will be noted and symptoms of nausea, fatigue, vomiting occur.

Once the threshold has been exceeded, the severity of an effect increases with dose. The reason for the presence of this threshold dose is that radiation damage (serious malfunction or death) of a critical population of cells (high doses tend to kill cells) in a given tissue needs to be sustained before injury is expressed in a clinically relevant form. Therefore, deterministic effects are also termed tissue reaction. They are also called non-stochastic effects to contrast with chance-like stochastic effects (e.g., cancer induction).

Deterministic effects are not necessarily more or less serious than stochastic effects. High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Acute doses below 250 mGy are unlikely to have any observable effects. Acute doses of about 3 to 5 Gy have a 50% chance of killing a person some weeks after the exposure, if a person receives no medical treatment. Deterministic effects can ultimately lead to a temporary nuisance or also to a fatality. Examples of deterministic effects:

Examples of deterministic effects are:

  • Acute radiation syndrome, by acute whole-body radiation
  • Radiation burns, from radiation to a particular body surface
  • Radiation-induced thyroiditis, a potential side effect from radiation treatment against hyperthyroidism
  • Chronic radiation syndrome, from long-term radiation.
  • Radiation-induced lung injury, from for example radiation therapy to the lungs

Lethal Doses of Radiation

The lethal dose of radiation (LD) is an indication of the lethal amount radiation. In radiation protection, the median lethal dose, LDXY, is usually used. For example, the dose of radiation expected to cause death to 50 % of the irradiated persons within 30 days is LD50/30.  LD1 is the dose expected to cause death to 1% of the irradiated persons, consequently, LD99 is lethal for all (99%) persons irradiated. It is also very important, whether a person receives some medical treatment or not. The greater an acute radiation dose is, the greater is the possibility of it killing the individual. For a healthy adult, the LD50 is estimated to be somewhere between 3 and 5 Gy.

  • 2.5 Sv – Dose that kills a human with a 1% risk (LD1), if the dose is received over a very short duration.
  • 5 Sv – Dose that kills a human with a 50% risk within 30 days (LD50/30), if the dose is received over a very short duration. Cause of death will be loss of bone marrow function.
  • 8 Sv – Dose that kills a human with a 99% risk (LD99), if the dose is received over a very short duration. At around 10 Gy, acute inflammation of the lungs can occur and lead to death.

The lethal dose data given above apply to acute gamma doses delivered in a very short time, e.g.,, a few minutes. More dose is required to produce the effects listed above, if the dose is received over a period of hours or longer.

Deterministic Effects and Dose Limits

In radiation protection, dose limits are set to limit stochastic effects to an acceptable level, and to prevent deterministic effects completely. Note that, stochastic effects are those arising from chance: the greater the dose, the more likely the effect. Deterministic effects are those which normally have a threshold: above this, the severity of the effect increases with the dose. Dose limits are a fundamental component of radiation protection, and breaching these limits is against radiation regulation in most countries. Note that, the dose limits described in this article apply to routine operations. They do not apply to an emergency situation when human life is endangered. They do not apply in emergency exposure situations where an individual is attempting to prevent a catastrophic situation.

The limits are split into two groups, the public, and occupationally exposed workers. According to ICRP, occupational exposure refers to all exposure incurred by workers in the course of their work, with the exception of

  1. excluded exposures and exposures from exempt activities involving radiation or exempt sources
  2. any medical exposure
  3. the normal local natural background radiation.

The following table summarizes dose limits for occupationally exposed workers and for the public:

dose limits - radiation
Table of dose limits for occupationally exposed workers and for the public.
Source of data: ICRP, 2007. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Ann. ICRP 37 (2-4).

According to the recommendation of the ICRP in its statement on tissue reactions of 21. April 2011, the equivalent dose limit for the lens of the eye for occupational exposure in planned exposure situations was reduced from 150 mSv/year to 20 mSv/year, averaged over defined periods of 5 years, with no annual dose in a single year exceeding 50 mSv.

Limits on effective dose are for the sum of the relevant effective doses from external exposure in the specified time period and the committed effective dose from intakes of radionuclides in the same period. For adults, the committed effective dose is computed for a 50-year period after intake, whereas for children it is computed for the period up to age 70 years. The effective whole-body dose limit of 20 mSv is an average value over five years. The real limit is 100 mSv in 5 years, with not more than 50 mSv in any one year.


Radiation Protection:

  1. Knoll, Glenn F., Radiation Detection and Measurement 4th Edition, Wiley, 8/2010. ISBN-13: 978-0470131480.
  2. Stabin, Michael G., Radiation Protection and Dosimetry: An Introduction to Health Physics, Springer, 10/2010. ISBN-13: 978-1441923912.
  3. Martin, James E., Physics for Radiation Protection 3rd Edition, Wiley-VCH, 4/2013. ISBN-13: 978-3527411764.
  5. U.S. Department of Energy, Nuclear Physics and Reactor Theory. DOE Fundamentals Handbook, Volume 1 and 2. January 1993.

Nuclear and Reactor Physics:

  1. J. R. Lamarsh, Introduction to Nuclear Reactor Theory, 2nd ed., Addison-Wesley, Reading, MA (1983).
  2. J. R. Lamarsh, A. J. Baratta, Introduction to Nuclear Engineering, 3d ed., Prentice-Hall, 2001, ISBN: 0-201-82498-1.
  3. W. M. Stacey, Nuclear Reactor Physics, John Wiley & Sons, 2001, ISBN: 0- 471-39127-1.
  4. Glasstone, Sesonske. Nuclear Reactor Engineering: Reactor Systems Engineering, Springer; 4th edition, 1994, ISBN: 978-0412985317
  5. W.S.C. Williams. Nuclear and Particle Physics. Clarendon Press; 1 edition, 1991, ISBN: 978-0198520467
  6. G.R.Keepin. Physics of Nuclear Kinetics. Addison-Wesley Pub. Co; 1st edition, 1965
  7. Robert Reed Burn, Introduction to Nuclear Reactor Operation, 1988.
  8. U.S. Department of Energy, Nuclear Physics and Reactor Theory. DOE Fundamentals Handbook, Volume 1 and 2. January 1993.
  9. Paul Reuss, Neutron Physics. EDP Sciences, 2008. ISBN: 978-2759800414.

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